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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1965 1
1975 1
1978 1
1979 2
1981 2
1982 2
1983 5
1986 3
1987 5
1988 2
1989 8
1990 11
1991 3
1992 12
1993 9
1994 12
1995 9
1996 15
1997 15
1998 18
1999 17
2000 18
2001 19
2002 26
2003 23
2004 23
2005 25
2006 28
2007 29
2008 31
2009 43
2010 51
2011 63
2012 65
2013 60
2014 48
2015 53
2016 50
2017 62
2018 60
2019 52
2020 54
2021 69
2022 54
2023 51
2024 24

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1,091 results

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Page 1
Evinacumab for Homozygous Familial Hypercholesterolemia.
Raal FJ, Rosenson RS, Reeskamp LF, Hovingh GK, Kastelein JJP, Rubba P, Ali S, Banerjee P, Chan KC, Gipe DA, Khilla N, Pordy R, Weinreich DM, Yancopoulos GD, Zhang Y, Gaudet D; ELIPSE HoFH Investigators. Raal FJ, et al. N Engl J Med. 2020 Aug 20;383(8):711-720. doi: 10.1056/NEJMoa2004215. N Engl J Med. 2020. PMID: 32813947 Clinical Trial.
This disorder is associated with genetic variants that result in virtually absent (null-null) or impaired (non-null) LDL-receptor activity. Loss-of-function variants in the gene encoding angiopoietin-like 3 (ANGPTL3) are associated with hypolipidemia and protection …
This disorder is associated with genetic variants that result in virtually absent (null-null) or impaired (non-null) LDL-receptor activity. …
Subspace-based non-blind deconvolution.
Zhuang PX, Ding XH, Duan JM. Zhuang PX, et al. Math Biosci Eng. 2019 Mar 14;16(4):2202-2218. doi: 10.3934/mbe.2019108. Math Biosci Eng. 2019. PMID: 31137207 Free article.
Meanwhile, with exploiting the difference of subspace priors, we put forward differentiation modelings on different subspace priors for improving deblurring performance. Then we utilize the least square integration method to fuse deblurred estimations and to compens …
Meanwhile, with exploiting the difference of subspace priors, we put forward differentiation modelings on different subspace priors for impr …
Identification effect of least square fitting method in archives management.
Ding C, Liang H, Lin N, Xiong Z, Li Z, Xu P. Ding C, et al. Heliyon. 2023 Sep 12;9(9):e20085. doi: 10.1016/j.heliyon.2023.e20085. eCollection 2023 Sep. Heliyon. 2023. PMID: 37810118 Free PMC article.
Solving the problem of identifying and classifying archives is essential for promoting the development of archives management. The Least Squares Support Vector Machine (LS-SVM) is obtained by introducing the least squares fitting method into SVM, which …
Solving the problem of identifying and classifying archives is essential for promoting the development of archives management. The Least …
Early neuromuscular electrical stimulation to improve quadriceps muscle strength after total knee arthroplasty: a randomized controlled trial.
Stevens-Lapsley JE, Balter JE, Wolfe P, Eckhoff DG, Kohrt WM. Stevens-Lapsley JE, et al. Phys Ther. 2012 Feb;92(2):210-26. doi: 10.2522/ptj.20110124. Epub 2011 Nov 17. Phys Ther. 2012. PMID: 22095207 Free PMC article. Clinical Trial.
Finally, some patients reached the maximum stimulator output during at least one treatment session and may have tolerated more stimulation. CONCLUSIONS: The early addition of NMES effectively attenuated loss of quadriceps muscle strength and improved functional …
Finally, some patients reached the maximum stimulator output during at least one treatment session and may have tolerated more stimul …
Towards Safe Weakly Supervised Learning.
Li YF, Guo LZ, Zhou ZH. Li YF, et al. IEEE Trans Pattern Anal Mach Intell. 2021 Jan;43(1):334-346. doi: 10.1109/TPAMI.2019.2922396. Epub 2020 Dec 4. IEEE Trans Pattern Anal Mach Intell. 2021. PMID: 31199253
This brings multiple advantages to safe weakly supervised learning. First, for many commonly used convex loss functions in classification and regression, it is guaranteed to derive a safe prediction under a mild condition. ...Finally, it is in an intuitive geometric …
This brings multiple advantages to safe weakly supervised learning. First, for many commonly used convex loss functions in cla …
Evaluating the association of biallelic OGDHL variants with significant phenotypic heterogeneity.
Lin SJ, Vona B, Lau T, Huang K, Zaki MS, Aldeen HS, Karimiani EG, Rocca C, Noureldeen MM, Saad AK, Petree C, Bartolomaeus T, Abou Jamra R, Zifarelli G, Gotkhindikar A, Wentzensen IM, Liao M, Cork EE, Varshney P, Hashemi N, Mohammadi MH, Rad A, Neira J, Toosi MB, Knopp C, Kurth I, Challman TD, Smith R, Abdalla A, Haaf T, Suri M, Joshi M, Chung WK, Moreno-De-Luca A, Houlden H, Maroofian R, Varshney GK. Lin SJ, et al. Genome Med. 2023 Nov 29;15(1):102. doi: 10.1186/s13073-023-01258-4. Genome Med. 2023. PMID: 38031187 Free PMC article.
We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl, ogdh paralogs, and dhtkd1 to investigate functional relationships and impact during development. Functional complementation with patient variant transcripts was conducted to systematically assess protein …
We used CRISPR/Cas9 to generate zebrafish knockouts of ogdhl, ogdh paralogs, and dhtkd1 to investigate functional relationships and i …
Efficacy confirmation study of aceneuramic acid administration for GNE myopathy in Japan.
Mori-Yoshimura M, Suzuki N, Katsuno M, Takahashi MP, Yamashita S, Oya Y, Hashizume A, Yamada S, Nakamori M, Izumi R, Kato M, Warita H, Tateyama M, Kuroda H, Asada R, Yamaguchi T, Nishino I, Aoki M. Mori-Yoshimura M, et al. Orphanet J Rare Dis. 2023 Aug 11;18(1):241. doi: 10.1186/s13023-023-02850-y. Orphanet J Rare Dis. 2023. PMID: 37568154 Free PMC article. Clinical Trial.
RESULTS: A total of 14 patients were enrolled and given SA-ER (n = 10) or placebo (n = 4) tablets orally. Decrease in least square mean (LSM) change in UEC score at Week 48 with SA-ER (- 0.115 kg) was numerically smaller as compared with placebo (- 2.625 kg), with L …
RESULTS: A total of 14 patients were enrolled and given SA-ER (n = 10) or placebo (n = 4) tablets orally. Decrease in least square …
Generalized n-Dimensional Rigid Registration: Theory and Applications.
Wu J, Wang M, Fourati H, Li H, Zhu Y, Zhang C, Jiang Y, Hu X, Liu M. Wu J, et al. IEEE Trans Cybern. 2023 Feb;53(2):927-940. doi: 10.1109/TCYB.2022.3168938. Epub 2023 Jan 13. IEEE Trans Cybern. 2023. PMID: 35507617
The generalized rigid registration problem in high-dimensional Euclidean spaces is studied. The loss function is minimized with an equivalent error formulation by the Cayley formula. The closed-form linear least-square solution to such a problem is der …
The generalized rigid registration problem in high-dimensional Euclidean spaces is studied. The loss function is minimized wit …
Mitochondrial function-associated genes underlie cortical atrophy in prodromal synucleinopathies.
Rahayel S, Tremblay C, Vo A, Misic B, Lehéricy S, Arnulf I, Vidailhet M, Corvol JC; ICEBERG Study Group; Gagnon JF, Postuma RB, Montplaisir J, Lewis S, Matar E, Ehgoetz Martens K, Borghammer P, Knudsen K, Hansen AK, Monchi O, Gan-Or Z, Dagher A; Alzheimer’s Disease Neuroimaging Initiative. Rahayel S, et al. Brain. 2023 Aug 1;146(8):3301-3318. doi: 10.1093/brain/awad044. Brain. 2023. PMID: 36826230 Free PMC article.
We then used structural and functional neighbourhood analyses to assess whether the atrophy patterns in iRBD were constrained by the brain's structural and functional connectome. ...Moreover, we demonstrated that cortical thinning was constrained by the brain's stru …
We then used structural and functional neighbourhood analyses to assess whether the atrophy patterns in iRBD were constrained by the …
Robust C-Loss Kernel Classifiers.
Xu G, Hu BG, Principe JC. Xu G, et al. IEEE Trans Neural Netw Learn Syst. 2018 Mar;29(3):510-522. doi: 10.1109/TNNLS.2016.2637351. Epub 2016 Dec 29. IEEE Trans Neural Netw Learn Syst. 2018. PMID: 28055924
The correntropy-induced loss (C-loss) function has the nice property of being robust to outliers. ...After using the half-quadratic optimization algorithm, which converges much faster than the gradient optimization algorithm, we find out that the resulting C- …
The correntropy-induced loss (C-loss) function has the nice property of being robust to outliers. ...After using the ha …
1,091 results